AustralieFrV1, Main, Exploration, bibRecord, 002514

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Identifieur interne : 002514 ( Main/Exploration ); précédent : 002513; suivant : 002515

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Auteurs : Monica Rolando [France] ; Pedro Escoll [France] ; Tamara Nora [France] ; Joëlle Botti [France] ; Valérie Boitez [France] ; Carmen Bedia [France] ; Craig Daniels [Canada] ; Gilu Abraham [Australie] ; Peter J. Stogios [Canada] ; Tatiana Skarina [Canada] ; Charlotte Christophe [France] ; Delphine Dervins-Ravault [France] ; Christel Cazalet [France] ; Hubert Hilbi [Suisse] ; Thusitha W. T. Rupasinghe [Australie] ; Dedreia Tull [Australie] ; Malcolm J. Mcconville [Australie] ; Sze Ying Ong [Australie] ; Elizabeth L. Hartland [Australie] ; Patrice Codogno [France] ; Thierry Levade [France] ; Thomas Naderer [Australie] ; Alexei Savchenko [Canada] ; Carmen Buchrieser [France]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.

RBID : PMC:4763766

Descripteurs français

KwdFr :
- Aldehyde-lyases (), Aldehyde-lyases (métabolisme), Animaux, Autophagie, Conformation des protéines, Cristallographie aux rayons X, Domaine catalytique, Legionella pneumophila (enzymologie), Maladie des légionnaires (immunologie), Souris, Sphingolipides (métabolisme).
MESH :
- enzymologie : Legionella pneumophila.
- immunologie : Maladie des légionnaires.
- métabolisme : Aldehyde-lyases, Sphingolipides.
- Aldehyde-lyases, Animaux, Autophagie, Conformation des protéines, Cristallographie aux rayons X, Domaine catalytique, Souris.

English descriptors

KwdEn :
- Aldehyde-Lyases (chemistry), Aldehyde-Lyases (metabolism), Animals, Autophagy, Catalytic Domain, Crystallography, X-Ray, Legionella pneumophila (enzymology), Legionnaires' Disease (immunology), Mice, Protein Conformation, Sphingolipids (metabolism).
MESH :
- chemical , chemistry : Aldehyde-Lyases.
- chemical , metabolism : Aldehyde-Lyases, Sphingolipids.
- enzymology : Legionella pneumophila.
- immunology : Legionnaires' Disease.
- Animals, Autophagy, Catalytic Domain, Crystallography, X-Ray, Mice, Protein Conformation.

Abstract

Significance

Legionella pneumophila is the causative agent of Legionnaires’ disease. It translocates a large repertoire of effectors into the host cell through a specialized secretion system to subvert cellular defenses. A key characteristic of this pathogen is that the majority of its effectors are encoded by eukaryotic-like genes acquired through horizontal gene transfer. We determined the crystal structure of one of these effectors, sphingosine-1 phosphate lyase (LpSpl), and show that it has high similarity with its eukaryotic homologue. We demonstrate that LpSpl possesses lyase activity and that it disrupts sphingolipid metabolism in the host cells. LpSpl plays a critical and previously unknown role in decreasing autophagy and is a unique virulence factor facilitating intracellular replication of L. pneumophila.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763766

DOI: 10.1073/pnas.1522067113
PubMed: 26831115
PubMed Central: 4763766

Affiliations:

Australie, Canada, France, Suisse

Le document en format XML

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 S1P-lyase targets host sphingolipid metabolism and restrains autophagy</title>
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<author><name sortKey="Hilbi, Hubert" sort="Hilbi, Hubert" uniqKey="Hilbi H" first="Hubert" last="Hilbi">Hubert Hilbi</name>
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<author><name sortKey="Rupasinghe, Thusitha W T" sort="Rupasinghe, Thusitha W T" uniqKey="Rupasinghe T" first="Thusitha W. T." last="Rupasinghe">Thusitha W. T. Rupasinghe</name>
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</nlm:aff>
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;</nlm:aff>
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<author><name sortKey="Levade, Thierry" sort="Levade, Thierry" uniqKey="Levade T" first="Thierry" last="Levade">Thierry Levade</name>
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;</nlm:aff>
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<author><name sortKey="Savchenko, Alexei" sort="Savchenko, Alexei" uniqKey="Savchenko A" first="Alexei" last="Savchenko">Alexei Savchenko</name>
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, Toronto,<country>Canada</country>
 M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
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 S1P-lyase targets host sphingolipid metabolism and restrains autophagy</title>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris Descartes-Sorbonne Paris Cité</institution>
, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boitez, Valerie" sort="Boitez, Valerie" uniqKey="Boitez V" first="Valérie" last="Boitez">Valérie Boitez</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut Necker Enfants-Malades</institution>
, INSERM U1151-CNRS UMR 8253, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris Descartes-Sorbonne Paris Cité</institution>
, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bedia, Carmen" sort="Bedia, Carmen" uniqKey="Bedia C" first="Carmen" last="Bedia">Carmen Bedia</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">INSERM UMR1037,<institution>Centre de Recherches en Cancérologie de Toulouse</institution>
, 31432 Toulouse,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daniels, Craig" sort="Daniels, Craig" uniqKey="Daniels C" first="Craig" last="Daniels">Craig Daniels</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
 M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abraham, Gilu" sort="Abraham, Gilu" uniqKey="Abraham G" first="Gilu" last="Abraham">Gilu Abraham</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute,<institution>Monash University</institution>
, Clayton, VIC 3800,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stogios, Peter J" sort="Stogios, Peter J" uniqKey="Stogios P" first="Peter J." last="Stogios">Peter J. Stogios</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
 M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Skarina, Tatiana" sort="Skarina, Tatiana" uniqKey="Skarina T" first="Tatiana" last="Skarina">Tatiana Skarina</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
 M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
 UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
 UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
 UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hilbi, Hubert" sort="Hilbi, Hubert" uniqKey="Hilbi H" first="Hubert" last="Hilbi">Hubert Hilbi</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Medical Microbiology,<institution>University of Zürich</institution>
,<country>8006, Zurich, Switzerland</country>
;</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rupasinghe, Thusitha W T" sort="Rupasinghe, Thusitha W T" uniqKey="Rupasinghe T" first="Thusitha W. T." last="Rupasinghe">Thusitha W. T. Rupasinghe</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tull, Dedreia" sort="Tull, Dedreia" uniqKey="Tull D" first="Dedreia" last="Tull">Dedreia Tull</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10">Department of Biochemistry and Molecular Biology,<institution>The University of Melbourne</institution>
, Melbourne, VIC 3010,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ong, Sze Ying" sort="Ong, Sze Ying" uniqKey="Ong S" first="Sze Ying" last="Ong">Sze Ying Ong</name>
<affiliation wicri:level="1"><nlm:aff id="aff11">Department of Microbiology and Immunology,<institution>University of Melbourne at the Peter Doherty Institute for Infection and Immunity</institution>
, Melbourne, VIC 3010,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="1"><nlm:aff id="aff11">Department of Microbiology and Immunology,<institution>University of Melbourne at the Peter Doherty Institute for Infection and Immunity</institution>
, Melbourne, VIC 3010,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut Necker Enfants-Malades</institution>
, INSERM U1151-CNRS UMR 8253, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris Descartes-Sorbonne Paris Cité</institution>
, 75993 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levade, Thierry" sort="Levade, Thierry" uniqKey="Levade T" first="Thierry" last="Levade">Thierry Levade</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">INSERM UMR1037,<institution>Centre de Recherches en Cancérologie de Toulouse</institution>
, 31432 Toulouse,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naderer, Thomas" sort="Naderer, Thomas" uniqKey="Naderer T" first="Thomas" last="Naderer">Thomas Naderer</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute,<institution>Monash University</institution>
, Clayton, VIC 3800,<country>Australia</country>
;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Savchenko, Alexei" sort="Savchenko, Alexei" uniqKey="Savchenko A" first="Alexei" last="Savchenko">Alexei Savchenko</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Department of Chemical Engineering and Applied Chemistry,<institution>University of Toronto</institution>
, Toronto,<country>Canada</country>
 M5S 3E5;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institut Pasteur,<institution>Biologie des Bactéries Intracellulaires</institution>
, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS</institution>
 UMR 3525, 75724 Paris,<country>France</country>
;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde-Lyases (chemistry)</term>
<term>Aldehyde-Lyases (metabolism)</term>
<term>Animals</term>
<term>Autophagy</term>
<term>Catalytic Domain</term>
<term>Crystallography, X-Ray</term>
<term>Legionella pneumophila (enzymology)</term>
<term>Legionnaires' Disease (immunology)</term>
<term>Mice</term>
<term>Protein Conformation</term>
<term>Sphingolipids (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aldehyde-lyases ()</term>
<term>Aldehyde-lyases (métabolisme)</term>
<term>Animaux</term>
<term>Autophagie</term>
<term>Conformation des protéines</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Legionella pneumophila (enzymologie)</term>
<term>Maladie des légionnaires (immunologie)</term>
<term>Souris</term>
<term>Sphingolipides (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aldehyde-Lyases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aldehyde-Lyases</term>
<term>Sphingolipids</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Legionella pneumophila</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Legionella pneumophila</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladie des légionnaires</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Legionnaires' Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aldehyde-lyases</term>
<term>Sphingolipides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Catalytic Domain</term>
<term>Crystallography, X-Ray</term>
<term>Mice</term>
<term>Protein Conformation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aldehyde-lyases</term>
<term>Animaux</term>
<term>Autophagie</term>
<term>Conformation des protéines</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p><italic>Legionella pneumophila</italic>
 is the causative agent of Legionnaires’ disease. It translocates a large repertoire of effectors into the host cell through a specialized secretion system to subvert cellular defenses. A key characteristic of this pathogen is that the majority of its effectors are encoded by eukaryotic-like genes acquired through horizontal gene transfer. We determined the crystal structure of one of these effectors, sphingosine-1 phosphate lyase (<italic>Lp</italic>
Spl), and show that it has high similarity with its eukaryotic homologue. We demonstrate that <italic>Lp</italic>
Spl possesses lyase activity and that it disrupts sphingolipid metabolism in the host cells. <italic>Lp</italic>
Spl plays a critical and previously unknown role in decreasing autophagy and is a unique virulence factor facilitating intracellular replication of <italic>L. pneumophila</italic>
.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Rolando, Monica" sort="Rolando, Monica" uniqKey="Rolando M" first="Monica" last="Rolando">Monica Rolando</name>
</noRegion>
<name sortKey="Bedia, Carmen" sort="Bedia, Carmen" uniqKey="Bedia C" first="Carmen" last="Bedia">Carmen Bedia</name>
<name sortKey="Boitez, Valerie" sort="Boitez, Valerie" uniqKey="Boitez V" first="Valérie" last="Boitez">Valérie Boitez</name>
<name sortKey="Boitez, Valerie" sort="Boitez, Valerie" uniqKey="Boitez V" first="Valérie" last="Boitez">Valérie Boitez</name>
<name sortKey="Botti, Joelle" sort="Botti, Joelle" uniqKey="Botti J" first="Joëlle" last="Botti">Joëlle Botti</name>
<name sortKey="Botti, Joelle" sort="Botti, Joelle" uniqKey="Botti J" first="Joëlle" last="Botti">Joëlle Botti</name>
<name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name>
<name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<name sortKey="Cazalet, Christel" sort="Cazalet, Christel" uniqKey="Cazalet C" first="Christel" last="Cazalet">Christel Cazalet</name>
<name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<name sortKey="Christophe, Charlotte" sort="Christophe, Charlotte" uniqKey="Christophe C" first="Charlotte" last="Christophe">Charlotte Christophe</name>
<name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<name sortKey="Dervins Ravault, Delphine" sort="Dervins Ravault, Delphine" uniqKey="Dervins Ravault D" first="Delphine" last="Dervins-Ravault">Delphine Dervins-Ravault</name>
<name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<name sortKey="Escoll, Pedro" sort="Escoll, Pedro" uniqKey="Escoll P" first="Pedro" last="Escoll">Pedro Escoll</name>
<name sortKey="Levade, Thierry" sort="Levade, Thierry" uniqKey="Levade T" first="Thierry" last="Levade">Thierry Levade</name>
<name sortKey="Nora, Tamara" sort="Nora, Tamara" uniqKey="Nora T" first="Tamara" last="Nora">Tamara Nora</name>
<name sortKey="Nora, Tamara" sort="Nora, Tamara" uniqKey="Nora T" first="Tamara" last="Nora">Tamara Nora</name>
<name sortKey="Rolando, Monica" sort="Rolando, Monica" uniqKey="Rolando M" first="Monica" last="Rolando">Monica Rolando</name>
</country>
<country name="Canada"><noRegion><name sortKey="Daniels, Craig" sort="Daniels, Craig" uniqKey="Daniels C" first="Craig" last="Daniels">Craig Daniels</name>
</noRegion>
<name sortKey="Savchenko, Alexei" sort="Savchenko, Alexei" uniqKey="Savchenko A" first="Alexei" last="Savchenko">Alexei Savchenko</name>
<name sortKey="Skarina, Tatiana" sort="Skarina, Tatiana" uniqKey="Skarina T" first="Tatiana" last="Skarina">Tatiana Skarina</name>
<name sortKey="Stogios, Peter J" sort="Stogios, Peter J" uniqKey="Stogios P" first="Peter J." last="Stogios">Peter J. Stogios</name>
</country>
<country name="Australie"><noRegion><name sortKey="Abraham, Gilu" sort="Abraham, Gilu" uniqKey="Abraham G" first="Gilu" last="Abraham">Gilu Abraham</name>
</noRegion>
<name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<name sortKey="Mcconville, Malcolm J" sort="Mcconville, Malcolm J" uniqKey="Mcconville M" first="Malcolm J." last="Mcconville">Malcolm J. Mcconville</name>
<name sortKey="Naderer, Thomas" sort="Naderer, Thomas" uniqKey="Naderer T" first="Thomas" last="Naderer">Thomas Naderer</name>
<name sortKey="Ong, Sze Ying" sort="Ong, Sze Ying" uniqKey="Ong S" first="Sze Ying" last="Ong">Sze Ying Ong</name>
<name sortKey="Rupasinghe, Thusitha W T" sort="Rupasinghe, Thusitha W T" uniqKey="Rupasinghe T" first="Thusitha W. T." last="Rupasinghe">Thusitha W. T. Rupasinghe</name>
<name sortKey="Tull, Dedreia" sort="Tull, Dedreia" uniqKey="Tull D" first="Dedreia" last="Tull">Dedreia Tull</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Hilbi, Hubert" sort="Hilbi, Hubert" uniqKey="Hilbi H" first="Hubert" last="Hilbi">Hubert Hilbi</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

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